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Take this medication by mouth usually once a day in the morning, with or without food, or as directed by your doctor. If your doctor tells you to take this medication twice a day, take a dose in the morning and at noon. Dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Do not take more or less medication than prescribed. The maximum recommended dose for adults treated for obsessive-compulsive disorder and premenstrual dysphoric disorder is 80 mg per day. The maximum recommended dose for children with attention-deficit hyperactivity disorder (ADHD) treated for depression is 20 mg per day. It may take 4 weeks or longer before the full benefit of this drug takes effect. Inform your doctor if your condition persists or worsens.
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Nausea, loss of appetite, diarrhoea, dry mouth, trouble sleeping, dizziness, drowsiness, yawning, weakness, or sweating may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
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Tell your doctor immediately if any of these serious side effects occur: unusual or severe mental/mood changes (e.g., anxiety, mania), weight loss, change in sexual desire and ability, vision changes. Tell your doctor immediately if any of these unlikely but serious side effects occur: uncontrolled movements (tremor), fever/flu-like symptoms. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: unusual muscle stiffness, fast/irregular heartbeats, chest pain, black stools, vomit that looks like coffee grounds, easy bruising/bleeding, unusual bleeding, seizures. For males, in the very unlikely event you have a painful, prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention or permanent problems could occur. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
- Do not use with an MAOI or within 14 days of discontinuing an MAOI due to the risk of drug interaction. At least 5 weeks should be allowed after stopping PROZAC before treatment with an MAOI
- Do not use with pimozide due to the risk of drug interaction or QTc prolongation (4, 7.9)
- Do not use with thioridazine due to QTc interval prolongation or potential for elevated thioridazine plasma levels. Do not use thioridazine within 5 weeks of discontinuing PROZAC (4, 7.9)
- When using PROZAC and olanzapine in combination, also refer to the Contraindications section of the package insert for Symbyax