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Dosage and Administration
ABSTRAL/Fentanyl Citrate/Fentora Sublingual Tablet, SL: 100mcg, 200mcg, 300mcg, 400mcg, 600mcg, 800mcg.
Actiq/Fentanyl Citrate Buccal Lozenge: 200mcg, 400mcg, 600mcg, 800mcg, 1200mcg, 1600mcg.
Actiq/Fentanyl Citrate Transmucosal Lozenge: 200mcg, 400mcg, 600mcg, 800mcg, 1200mcg, 1600mcg..
Duragesic/Fentanyl Transdermal Film ER: 1h, 12mcg, 25mcg, 37.5mcg, 50mcg, 62.5mcg, 75mcg, 87.5mcg, 100mcg
Fentanyl Citrate/Fentora Buccal Tablet, SL: 100mcg, 200mcg, 400mcg, 600mcg, 800mcg.
Fentanyl Citrate/Fentora Transmucosal Tablet, SL: 100mcg, 200mcg, 400mcg, 600mcg, 800mcg.
Fentanyl Citrate/Sublimaze Intramuscular Injection Sol: 1mL, 50mcg.
Fentanyl Citrate/Sublimaze Intravenous Injection Sol: 1mL, 50mcg.
IONSYS Transdermal Patch, Electrically Controlled: 1actuation, 40mcg.
Lazanda Nasal Spray Met: 1actuation, 100mcg, 300mcg, 400mcg.
Lazanda Transmucosal Spray Met: 1actuation, 100mcg, 300mcg, 400mcg.
SUBSYS Sublingual Spray Met: 1actuation, 100mcg, 200mcg, 400mcg, 600mcg, 800mcg.
Dosage should be individualized according to age, bodyweight, physical status, underlying pathological condition, use of other drugs, type of anaesthesia to be used and the surgical procedure involved.
For the management of severe breakthrough cancer pain in opioid-tolerant patients.
Transmucosal dosage (e.g. Actiq oral lozenge or generic equivalents ONLY)
Adults and Adolescents 16 years and older
Initially, a single 200-mcg lozenge (Actiq) placed between the cheek and lower gum as needed for breakthrough pain. The unit should be sucked, not chewed, over a period of 15 minutes. If pain is not relieved within 15 minutes after complete consumption, may repeat dose once. Max: 2 lozenge units/breakthrough pain episode. Do not repeat additional dosing for at least 4 hours.
Low Dose: 2 mcg/kg (0.002 mg/kg) (0.04 mL/kg). For use in minor, but painful, surgical procedures. May also provide some pain relief in the immediate postoperative period. 2 mcg/kg (0.002 mg/kg) (0.04 mL/kg). Additional dosages are infrequently needed in these minor procedures. Buy Fentanyl Citrate Online
Moderate Dose: 2-20 mcg/kg (0.002-0.02 mg/kg) (0.04-0.4 mL/kg). For use in major surgical procedures, in addition to adequate analgesia. 2-20 mcg/kg (0.002-0.02 mg/kg) (0.04-0.4 mL/kg). 25 to 100 mcg (0.025 to 0.1 mg) (0.5 to 2 mL) Administer intravenously or intramuscularly as needed when movement and/or changes in vital signs indicate surgical stress or lightening of analgesia.
High Dose – 20-50 mcg/kg (0.02-0.05 mg/kg) (0.4-1 mL/kg). For open heart surgery and certain more complicated neurosurgical and orthopedic procedures where surgery is more prolonged, and the stress response to surgery would be detrimental to the wellbeing of the patient. 20-50 mcg/kg (0.02-0.05 mg/kg) (0.4-1 mL/kg). Maintenance dosage [ranging from 25 mcg (0.025 mg) (0.5 mL) to one half the initial loading dose] as needed based on vital signs changes indicative of stress and lightening of analgesia.
Fentanyl Citrate Injection SDZ and Fentanyl Citrate Injection USP should be used with caution within 12 hours pre-operatively and within the first 12-24 hours post-operatively. 100 mcg (0.05 to 0.1 mg) (1 to 2 mL) may be administered intramuscularly or slowly intravenously, over one to two minutes, when additional analgesia is required.
Postoperatively (recovery room)
50 to 100 mcg (0.05 to 0.1 mg) (1 to 2 mL) may be administered intramuscularly for the control of pain, tachypnea and emergence delirium. The dose may be repeated in one to two hours as needed.
For Induction And Maintenance In Children 2 to 12 Years Of Age
A reduced dose as low as 2 to 3 mcg/kg is recommended.
As A General Anesthetic
As a technique to attenuate the responses to surgical stress without the use of additional anesthetic agents, doses of 50 to 100 mcg/kg (0.05 to 0.1 mg/kg) (1 to 2 mL/kg) may be administered with oxygen and a muscle relaxant.
For the control of moerate pain or severe pain.
Intravenous or Intramuscular dosage
50 to 100 mcg IM, or by slow IV over 1 to 2 minutes, given 30 to 60 minutes before surgery.
For control of postoperative pain in the recovery room.
Intravenous or Intramuscular dosage
50 to 100 mcg IM or slow IV over 1 to 2 minutes for the control of pain, tachypnea, and/or delirium. The dose may be repeated in 1 to 2 hours, as needed.
Children† and Adolescents 2 years and older
0.5 to 2 mcg/kg/dose IV or IM every 1 to 2 hours as needed for pain relief. Max initial dose: 50 mcg.
Infants† and Children† through 1 year of age 0.5 to 2 mcg/kg/dose IV or IM every 1 to 2 hours as needed for pain relief.
0.5 to 3 mcg/kg/dose IV every 2 to 4 hours as needed.
Patients must require and use around-the-clock opioids when taking Actiq.
Initial dose of Actiq: 200 mcg. Prescribe an initial supply of six 200 mcg Actiq units.
Individually titrate to a tolerable dose that provides adequate analgesia
using single Actiq dosage unit per breakthrough cancer pain episode.
No more than two doses can be taken per breakthrough pain episode.
-Wait at least 4 hours before treating another episode of breakthrough pain with Actiq.
-Limit consumption to four or fewer units per day once successful dose is found.
As with all opioids, the safety of patients using such products is dependent on health care professionals prescribing them in strict conformity with their approved labeling with respect to patient selection, dosing, and proper conditions for use. Actiq comes in forms such as ;Solid oral transmucosal lozenge in 200 mcg, 400 mcg, 600 mcg, 800 mcg, 1200 mcg and 1600 mcg. Buy Pain Pills Online
DOSAGE FORMS AND STRENGTHS.
Solid oral trans mucosal lozenge in 200 mcg, 400 mcg, 600 mcg, 800 mcg, 1200 mcg and 1600 mcg.
Side effects include; Slow heart rate; weak or shallow breathing, extreme sleepiness, nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, or headache may occur. Pain, sores, or irritation in the mouth (where the medication has been applied) may also occur. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Buy Fentanyl Citrate Online
Life-Threatening Respiratory Depression, Sleepiness (Somnolence), Slowed Breathing or Low Blood Pressure, Adrenal Insufficiency, Seizures, Gastrointestinal Adverse Reactions, Nausea, rapid breathing, sneezing, anxiety, weakness, pale skin, sunken eyes, pounding in the ears, sore throat, vomiting, dizziness, headache, dry mouth, constipation, lightheadedness, dizziness, drowsiness, or headache may occur. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
DURAGESIC is contraindicated in the following patients and situations:
in patients who are not opioid-tolerant, Known fentanyl hypersensitivity, in patients with decreased function of the adrenal gland, in patients with drug abuse, in patients with alcohol intoxication, in patients with inflammatory bowel disease, in patients with low blood pressure, in the management of acute or intermittent pain, or in patients who require opioid analgesia for a short period of time, in patients with significant respiratory compromise, especially if adequate monitoring and resuscitative equipment are not readily available.
-Opioid non-tolerant patients.
-Management of acute or postoperative pain including headache/migraines and dental pain.
-Intolerance or hypersensitivity to fentanyl or components of Actiq.
WARNINGS AND PRECAUTIONS
Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), kidney disease, liver disease, mental/mood disorders (such as confusion, depression), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), difficulty urinating (such as due to enlarged prostate), gallbladder disease, disease of the pancreas
-Clinically significant respiratory and CNS depression can occur. Monitor patients accordingly.
-Full and partially consumed Actiq units contain medicine that can be fatal to a child. Ensure proper storage and disposal. Interim safe storage container available (ACTIQ Child Safety Kit).
Before taking Fentanyl, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
-Use with other CNS depressants and potent cytochrome P450 3A4 inhibitors may increase depressant effects including respiratory depression, hypotension, and profound sedation. Buy Pain Pills Online . Consider dosage adjustments if warranted. Wiki